The pediatric randomized carvedilol trial in children with chronic heart failure: Rationale and design
نویسندگان
چکیده
with chronic heart failure: Rationale and design Robert E. Shaddy, MD, E. Leigh Curtin, MD, Brett Sower, RPh, Lloyd Y. Tani, MD, Jeri Burr, RNC, CCRC, Bernard LaSalle, BS, Mark M. Boucek, MD, Lynn Mahony, MD, Daphne T. Hsu, MD, Elfriede Pahl, MD, Grant H. Burch, MD, and Rozsa Schlencker-Herceg, MD, for The Pediatric Randomized Carvedilol Trial in Children with Heart Failure Study Salt Lake City, Utah, Westminster, Colo, Dallas, Tex, New York, NY, Chicago, Ill, Portland, Ore, and Collegeville, Pa
منابع مشابه
Rationale and design of the Children’s Oncology Group (COG) study ALTE1621: a randomized, placebo-controlled trial to determine if low-dose carvedilol can prevent anthracycline-related left ventricular remodeling in childhood cancer survivors at high risk for developing heart failure
BACKGROUND Anthracyclines are widely used in the treatment of childhood cancer. One of the well-recognized side-effects of anthracycline therapy is dose-dependent cardiomyopathy that may progress to heart failure (HF) years after completion of cancer-directed therapy. This study will evaluate the efficacy of low-dose beta-blocker (carvedilol) for HF risk reduction in childhood cancer survivors ...
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BACKGROUND Adrenergic receptor blockers used in the treatment of heart failure have distinct receptor affinity profiles. We hypothesized that alpha-adrenergic-blocking effects of carvedilol would limit vasoconstriction in response to adrenergic stimuli when compared with metoprolol. METHODS AND RESULTS Forearm vascular resistance responses to isometric handgrip and cold pressor test were dete...
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CONTEXT Although beta-blockers improve symptoms and survival in adults with heart failure, little is known about these medications in children and adolescents. OBJECTIVE To prospectively evaluate the effects of carvedilol in children and adolescents with symptomatic systemic ventricular systolic dysfunction. DESIGN, SETTING, AND PARTICIPANTS A multicenter, randomized, double-blind, placebo-...
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Background: Statins frequently cause myopathy especially in combination with fibrates, and physical activity is considered a trigger for the muscle disorder. Elevated plasma levels of creatine kinase (CK), lactate dehydrogenase (LDH) and aldolase, are the main indicators of the severity of myopathy. Carvedilol is commonly used with lipid-lowering drugs in the management of heart failure, hypert...
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The rationale for beta-blockade in heart failure is now well established. Heart failure mortality, which is predicted by neurohormonal activation, remains high despite modern treatment including ACE inhibition, and additional neurohormonal blockade has further therapeutic potential. Previous clinical trial experience in heart failure, most of which has been in patients with idiopathic cardiomyo...
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